| Glamping Hub | glampinghub.com | Online marketplace for luxury/glamping outdoor accommodations. Dual HQ Sevilla + Denver. Founded 2013. | €1.5M | — | 2013 | 51-200 | Series A | — |
| Upbe (Predictiva) | upbe.ai | Conversational AI for call centers (automated QA, compliance, sales analysis). Operated by Predictiva Intelligence. Founded ~2016. | €3.7M | — | 2016 | 11-50 | Seed | — |
| Build to Zero | buildtozero.es | Thermal energy storage (ThermalBox) for industrial heat decarbonization. Founded 2022 in Sevilla. | €2.5M | — | 2022 | 11-50 | Seed | — |
| Ibancar | ibancar.com | Online car-title / collateralized consumer loans. Founded 2011 in Málaga. | €1.6M | — | 2011 | 11-50 | Seed | — |
| Cartel.es | cartel.es | LegalTech — mass consumer car-cartel price-fixing claims. Founded 2022 in Málaga. | €25.0M | — | 2022 | 11-50 | Unknown | — |
| RavenPack | ravenpack.com | NLP/analytics turning unstructured news/text into structured financial data; also Bigdata.com AI product. Founded 2003. | €35.0M | — | 2003 | 51-200 | Series +B | GP Bullhound,European Investment Bank (EIB) |
| Lendismart | lendismart.com | Point-of-sale financing marketplace connecting retail customers to lenders. Founded 2016. | — | — | 2016 | 11-50 | Seed | SeedRocket,Faraday Venture Partners |
| Adcities | adcities.com | Digital out-of-home (DOOH) geo-contextual adtech. Founded ~2021. | €3.0M | — | 2021 | 11-50 | Seed | Adara Ventures |
| DNActive | dnactive.com | Consumer genetics — DNA testing for health, nutrition and fitness insights. Founded ~2015/2016 in Granada. | €1.0M | — | 2015 | 1-10 | Seed | — |
| Tiendanimal | tiendanimal.es | Pet products ecommerce + omnichannel retail (60+ stores Spain/Portugal). Founded 2006 in Málaga. | €12.5M | — | 2006 | 501-1.000 | Series +B | Miura Partners,Muzinich & Co,LGT Capital Partners |
| Scoobic | scoobic.com | Electric vehicles for last-mile urban delivery. Founded 2015 in Dos Hermanas (Sevilla). | €11.7M | — | 2015 | 11-50 | Series A | EIT InnoEnergy |
| Bluumi | bluumi.net | No-code platform to build native iOS/Android apps for businesses. Founded 2010. | — | — | 2010 | 11-50 | Bootstrapped | — |
| Twenix | twenix.io | B2B English-conversation e-learning. Founded 2017 in Almería; operations now in Madrid. | €3.5M | — | 2017 | 11-50 | Series A | Inveready,374887eb-6e4e-818d-a7cf-d57e076c49bb,374887eb-6e4e-8167-801d-dee7a0fcfc77 |
| H2B2 | h2b2.es | Green hydrogen production / PEM electrolyzers; factory in Sevilla. Founded 2016. | €13.0M | — | 2016 | 51-200 | Bootstrapped | — |
| Mube | bemube.com | Urban mobility and travel experiences marketplace connecting tourists with verified local guides and activity providers across mid-sized Spanish cities. | — | — | 2023 | 1-10 | Seed | — |
| Pharmamel | pharmameldrugdiscovery.com | Drug discovery company focused on the therapeutic potential of melatonin and its analogues for neurological and oncological diseases. University of Granada spinoff. | €1.6M | — | 2014 | 1-10 | Bootstrapped | — |
| Zexel | zexel.io | B2B SaaS platform for project management and resource planning targeting creative agencies and professional services firms. | — | — | 2021 | 1-10 | Unknown | — |
| Flamingo Biomechanical Lab | flamingobiolab.com | MedTech startup developing biomechanical analysis systems for sports injury prevention and rehabilitation, combining wearable sensors and AI. | — | — | 2023 | 1-10 | Pre-seed | — |
| Grodi | groditech.com | Software and IoT infrastructure for greenhouse growers, enabling precision growing and supply chain traceability in industrial horticulture. | €2.5M | — | 2022 | 1-10 | Seed | Swanlaab Venture Factory |
| Adaion | adaion.energy | AI and data analytics platform for energy companies, providing demand forecasting, asset optimization, and sustainability reporting tools. | €2.6M | — | 2021 | 1-10 | Seed | Bolsa Social |
| HRider | hrider.es | HR software for employee feedback, performance reviews, and engagement surveys. Focused on SMEs and growing tech teams. | — | — | 2015 | 11-50 | Bootstrapped | — |
| FROGED | froged.com | Customer success platform combining in-app messaging, product analytics, and customer data management. Used by SaaS teams to reduce churn and improve activation. | €415K | — | 2019 | 11-50 | Seed | 374887eb-6e4e-813d-a4d2-ffa0500f776c,374887eb-6e4e-8167-801d-dee7a0fcfc77 |
| Adity | adity.es | B2B embedded finance platform offering credit and BNPL solutions for SMEs operating in digital marketplaces. | €250K | — | 2023 | 1-10 | Pre-seed | — |
| Agrow Analytics | agrowanalytics.com | Precision agriculture platform using satellite imagery and machine learning to monitor crop health and optimize irrigation decisions for farmers. | €650K | — | 2021 | 1-10 | Seed | — |
| Bioherent | bioherent.com | Biotech startup developing diagnostic tools based on biophotonics and optical coherence tomography for non-invasive tissue analysis. | €2.0M | — | 2021 | 1-10 | Pre-seed | — |
| AGPhotonics | ag-photonics.com | Photonics company developing high-performance optical components and integrated photonic systems for telecom and sensing applications. University of Málaga spinoff. | — | — | 2023 | 1-10 | Pre-seed | 374887eb-6e4e-811f-9c1e-f4ff6f3b89c6 |
| nanoMetic | nanometic.com | nanoMetic is the patented technology of nanoIntec, part of the Beyond Seeds Biotech Group. They design biomimetic nanoparticles derived from biomedical research (primarily calcium and phosphate compounds) for use as plant nutrition and protection carriers in agriculture. Active ingredients release only when triggered by the plant's own metabolism, enabling high bioavailability with zero toxic residue. Product lines: Nutritional, Protector, and Stimulant. Applications include antiviral solutions, Tuta absoluta control, and blossom-end rot treatment. | — | — | — | 1-10 | Seed | — |
| Eonesia | eonesia.com | Eonesia builds gamified, immersive learning experiences in virtual worlds — combining AI, advanced gamification, and immersive reality for education and corporate training. Their platform (Eonesia LXP) lets any user create interactive learning experiences without technical knowledge, including a Canva integration for template-based design. Clients include educational institutions, universities, hospitals, and the military. | — | — | — | 11-50 | Seed | — |
| Kyvrox | linkedin.com | Kyvrox is an offensive cybersecurity company combining AI-assisted pentesting with human expert teams to protect critical infrastructure. Their differentiator is a hybrid model — automated AI scanning plus certified security professionals — targeting a false positive rate of just 0.001%. Focus on critical infrastructure protection. | — | — | — | 1-10 | Pre-seed | — |
| Stemdo | stemdo.io | Stemdo is a Talent-as-a-Service platform that recruits, trains, and deploys certified tech professionals from high-unemployment Spanish regions to large corporate clients. It directly counters the brain-drain dynamic: instead of talent migrating to Madrid or Barcelona, Stemdo creates digital jobs in Huelva, Mérida, and Talavera de la Reina. The platform uses AI and blockchain for selection and monitoring. Two products: Talent as a Service (on-demand certified profiles) and Talent Builder (bespoke team creation).
| €700K | — | 2022 | 51-200 | Seed | — |
| Soleaheat | soleaheat.com | SoleaHeat is an industrial solar-thermal startup providing turnkey heat and cold supply for industrial processes — up to 300°C and down to -20°C — replacing fossil fuel consumption. They design and manufacture their own solar collectors (in the large small-scale range, patentable), develop and integrate full plants, and monetise through supplied energy. Target markets: water treatment, industrial production, and energy communities. | — | — | — | 1-10 | Pre-seed | — |
| Montevive.ai | montevive.ai | Montevive helps companies adopt AI safely — legally compliant, GDPR-ready, and without exposing sensitive data. Their core offering is a three-step service: a Shadow-AI Diagnostic (auditing undeclared AI use inside organisations), executive training, and ongoing compliance support. Their flagship product, Moviwa, is a middleware layer that blocks data leaks, prevents prompt injection, and ensures regulatory compliance in real time without disrupting workflow. | — | — | — | 1-10 | Pre-seed | — |
| Xtrem Biotech | spinoff.ugr.es | UGR spin-off from microbiologists (Research Group BIO-188). Extremophile biotech applications. | — | — | 2014 | 1-10 | Pre-seed | — |
| Graniot | graniot.com | Web app for agronomists and farmers to monitor crop plots weekly (vigor, chlorophyll, water stress via satellite/remote sensing). | €500K | — | 2022 | 1-10 | — | — |
| Firmafy | firmafy.com | Electronic signature platform for businesses. | — | — | 2019 | 11-50 | — | — |
| Genaq Technologies | genaq.com | Develops and industrializes atmospheric water generators (extracts drinkable water from air). Based at Parque Tecnológico de Córdoba. Recognized in APTE's Top 100. | — | — | 2008 | 1-10 | — | — |
| Mogu Platform | moguplatform.com | Vertical SaaS for travel agencies and tour operators: visual proposals, payment management, GIAV integration. Operating in 28 countries. Vision: AI-driven travel vertical SaaS. | €2.2M | — | 2020 | 11-50 | Seed | Andalucía Open Future |
| Biomixing | biomixing.com | Industrial biotech: optimization and scale-up of bioreactors applying aeronautics, fluid mechanics and numerical simulation to improve fermentation processes. | — | — | 2022 | 1-10 | Pre-seed | — |
| Solar MEMS Technologies | solar-mems.com | World-leading manufacturer of solar sensors, star trackers and horizon sensors for space systems (satellite attitude and orientation control). Sensors on dozens of international satellites. | — | — | 2008 | 11-50 | Unknown | Austral Venture Gestión |
| Genera Games | generagames.com | Mobile game developer specializing in puzzle/match-3 games. Top 75 worldwide in 2017. Declined Disney offer. Acquired in full by Scopely in October 2020. | — | — | 2005 | 51-200 | Bootstrapped | — |
| Viva Games Studios | vivastudios.com | Mobile game publisher spun off from Genera Games after the Scopely acquisition. Inherited published games catalogue. Continuing to publish (Mini Golf Champs, Real Car Racing Simulator, etc.). | — | — | 2020 | 11-50 | Pre-seed | — |
| Pegasus Aero Group | pegasusaerogroup.com | Design, manufacture and operation of unmanned platforms (UAVs/drones) for civil and military use. Includes advanced civil UAS simulator in the Canary Islands. | — | — | 2016 | 501-1.000 | Unknown | — |
| Duponte Group | duponteadn.com | Biotech and genomics company. MIT Forum Best Female-Led Startup award. Premio Andalucía Emprende. Recognized in El Referente Top female-led scaleups ranking in Spain. | — | — | 2019 | 11-50 | Pre-seed | — |
| OGA.ai | oga.ai | AI and process optimization company. AI and operations research models applied to large corporations. 60+ professionals linked to Grupo CÁTEDRA (13 university professors). | — | — | 2008 | 51-200 | Unknown | Andalucía Open Future |
| ec2ce | ec2ce.com | AgTech: predictive models and AI algorithms for the agrifood sector (productivity, pests, harvest, demand, fertigation). Clients in Spain, Portugal, Argentina, Peru and Colombia. | €1.0M | — | 2014 | 11-50 | Seed | Wayra,Andalucía Open Future |
| SDos | sdos.es | Sevillian IT services and consulting company. Acquired by French listed company Alten in 2019. Third Sevillian startup acquisition in 2019 alongside Bitnami and Geographica. | — | — | 2008 | 201-500 | Bootstrapped | — |
| Qamarero | qamarero.com | HoReCa Tech: digital solution for hospitality (order digitalization, payment processing, order management for restaurants and bars). | — | — | 2021 | 11-50 | Unknown | — |
| Exxita Be Circular | exxita.com | B2B circular economy: sustainable lifecycle management of IT and electronic equipment (refurbishment, second life, certified recycling). Revenue >€1M. Member of Founders Andalucía. | €7.8M | — | 2004 | 51-200 | Unknown | Andalucía Open Future,374887eb-6e4e-8198-8fd2-cb0204d331c7,Wayra |
| Bitnami | bitnami.com | Cloud application maintenance and installation platform (Amazon, Google, Microsoft). One of the most significant exits with Sevillian origins. Acquired by VMware in 2019. | — | — | 2003 | 51-200 | Unknown | Founders Andalucía |
| Z1 Digital Studio | z1.digital | Digital product studio for international tech startups. Design and development for clients in NY, Silicon Valley and Vancouver. Clients include LoftSmart, L'Oréal, Dell, Big Sky Health. | — | — | 2015 | 11-50 | Bootstrapped | — |
| Cultural Fit Solutions | minzer.io | Universidad de Sevilla spin-off. AI platform measuring candidate-company cultural fit based on shared values (CFAM® Method). Reduces failed hires by up to 80% and absenteeism by 50%. | €150K | — | 2021 | 1-10 | Pre-seed | Andalucía Open Future |
| Turbosuite | turbosuite.com | B2B technology company (limited public detail). Member of Founders Andalucía, implying revenue >€1M or private funding >€1M. | — | — | 2021 | 11-50 | Unknown | — |
| Geographica | geographica.gs | GIS and data science consultancy. Spatial intelligence products for Telefónica, Mastercard, Vodafone. Acquired by CARTO in 2019. 40% of pre-exit revenue from USA and France. | — | — | 2009 | 11-50 | Bootstrapped | — |
| AERTEC Solutions | aertecsolutions.com | Aerospace engineering and global consultancy (Spain, UAE, Europe). Leader in UAS systems (tactical class I TARSIS-ISTAR drones with ATOL technology). Spin-off AERTEC Defence & Aerial Systems created 2024. | — | — | 1997 | 501-1.000 | Bootstrapped | — |
| Plus Vitech | plusvitech.com | Spin-off from Hospital Virgen del Rocío (SAS). NK-1 receptor antagonists for cancer treatment (initially lung cancer). Complementary diagnostic test in blood plasma. | — | — | 2013 | 1-10 | Seed | — |
| Onestx | onestx.bio | Biotech for neurodegenerative diseases (Alzheimer, Huntington). Drug STX64 (Irosustat): oral steroid sulfatase (STS) inhibitor stabilizing endogenous sulfated neurosteroids. Clinical phase in humans late 2025. | €1.4M | — | 2020 | 1-10 | Seed | — |
| Odders Lab | odderslab.com | Independent VR/XR game studio. Direct client of Meta, Google, Apple and Pico (TikTok). Games include Les Mills BodyCombat VR (Best Meta App 2022, cited by Zuckerberg) and OhShape. | — | — | 2019 | 11-50 | Bootstrapped | Founders Andalucía |
| OpenWebinars | openwebinars.net | B2B e-learning platform for technology skills (programming, systems, AI, cybersecurity) using SENDA methodology. 750+ enterprise clients, 250,000+ professionals trained. | — | — | 2015 | 11-50 | Seed | Founders Andalucía,eoniq,4Founders Capital,+1 |
| Kampaoh | es.kampaoh.com | Glamping platform (equipped tents in campsites) across Spain, Portugal and France. Own industrial line: Kampaoh UP tents and Kampaoh GO campers. | €19.0M | — | 2016 | 51-200 | Series A | JME Ventures,Encomenda Smart Capital,Axon Partners Group,+1 |
| CoverManager | covermanager.com | SaaS for reservation management and CRM for premium restaurants (~800 Michelin-star clients). 17,000 customers in 40+ countries. Merged with Zenchef after PSG Equity acquisition. | €52.0M | — | 2015 | 201-500 | Series +B | — |
| Galgus | galgus.ai | DeepTech company with patented Cognitive Hotspot Technology (CHT) optimizing WiFi networks (+400% performance) and indoor geolocation. 9 international patents. Deployed in planes, trains, stadiums and cities. | €10.0M | — | 2012 | 51-200 | Series A | Andalucía Open Future,Mundi Ventures,374887eb-6e4e-81bc-a434-e898e37860af,+2 |
| Solum | solumpv.com | CleanTech: walkable solar tile (photovoltaic flooring) with no visual urban impact. Applications include micro-mobility charging stations, terraces and cycle lanes. Product Arena launched 2024. | €750K | — | 2019 | 1-10 | Seed | Andalucía Open Future,Austral Venture Gestión,Wayra,+1 |
| Universal DX | universaldx.com | Blood test for early-stage cancer detection (colon, lung, stomach, pancreas) based on epigenetics and ML. Strategic alliance with Quest Diagnostics. | €135.0M | — | 2012 | 51-200 | Series +B | Founders Andalucía,European Investment Bank (EIB),Quest Diagnostics,+1 |
| MyHixel | myhixel.com | MedTech for male sexual health. FDA and EU-certified medical devices + guided therapy app for premature ejaculation, erectile dysfunction and pelvic floor conditions. | €3.5M | — | 2017 | 11-50 | Seed | Zubi Capital |
| Silbo Money | silbo.money | Fintech for instant payments via WhatsApp (Bizum alternative). Authorized by Banco de España as electronic money institution. Transactional bot assistant. | €1.5M | — | 2021 | 1-10 | Seed | — |
| Catalyxx | catalyxxinc.com | Patented catalytic process converting bioethanol into biobutanol, biohexanol and biooctanol as petroleum alternatives for paints, adhesives, cosmetics and SAF fuels. | €18.0M | — | 2017 | 11-50 | Series A | Austral Venture Gestión,Axon Partners Group |
| Wuolah | wuolah.com | EdTech platform where university students upload notes and earn money per download via ad revenue. 2.5M+ registered students in 30+ countries across Spain and LatAm. | €8.0M | — | 2015 | 11-50 | Series A | eoniq,Alter Capital,Founders Andalucía,+1 |
| Inveert | inveert.com | B2B2C fintech for digital financial planning and advisory for financial institutions. AI algorithm advising small investors. Client: Cobas Pensiones. | €250K | — | 2020 | 11-50 | Pre-seed | — |
| Vaxdyn | vaxdyn.com | Biotech developing multi-pathogen vaccines to prevent antibiotic-resistant infections (AMR). Platform targeting over 1M deaths/year from drug-resistant bacteria. | €14.5M | — | 2011 | 1-10 | Series A | Arquimea |
| Glucube (iGluco) | glucube.com | World's first non-invasive glucometer using infrared technology to measure blood glucose without finger prick (>99% accuracy). Collaboration with ETSI-Universidad de Sevilla. | €800K | — | 2016 | 1-10 | Unknown | — |
| Grupo Mox | grupomox.com | Last-mile logistics with salaried delivery riders (differential model). Divisions: Mox (express delivery), DriverJobs, Vamox (e-commerce parcels), Mox Delivery (food delivery). White label for major clients. | €3.5M | — | 2016 | 501-1.000 | Seed | eoniq |
| Biomedal | biomedal.com | Biotech with Life Science division (metabolic engineering, CRO) and Diagnostics division (celiac tests Glutentox, iVYDAL, Oleotest). World leader in immunogenic gluten detection. | — | — | 2000 | 11-50 | Bootstrapped | — |
| Docline | docline.com | B2B telemedicine platform for insurers, hospitals, and pharma companies; 24/7 digital health services | €7.6M | — | 2016 | 11-50 | Series A | 374887eb-6e4e-815e-b4d9-c7019b95ca18,374887eb-6e4e-8124-a2c4-eedc45f7ec0e |
| EsDron | esdron.com | Precision agriculture services using AI-powered drones for crop monitoring and targeted foliar treatment | — | — | 2022 | 1-10 | Pre-seed | Andalucía Open Future |
| Futuralga | futuralga.com | Biodegradable packaging made from invasive marine algae; spin-off of Universidad de Cádiz | €285K | — | 2018 | 1-10 | Pre-seed | Andalucía Open Future,Austral Venture Gestión |
| Magnific (prev. Freepik) | magnific.com | AI creative platform for video and image generation; formerly Freepik, rebranded April 2026 | — | — | 2010 | 201-500 | Bootstrapped | — |
| Genially | genially.com | Interactive content creation platform for presentations, infographics, and educational materials | €20.0M | — | 2015 | 51-200 | Series +B | JME Ventures,645 Ventures,Owl Ventures,+1 |